Post by miamianne67 on Apr 17, 2019 14:16:35 GMT
* Note it will take @ 10 years more study
Miami Herald Logo
Are your antibiotics not working anymore? Arsenic could be a lifesaver, research says | Miami Herald
HEALTH & FITNESS
Are your antibiotics not working anymore? Arsenic could be a lifesaver, research says
BY HOWARD COHEN
APRIL 16, 2019 12:03 PM, UPDATED APRIL 16, 2019 02:52 PM
Bacteria are rebelling. They’re turning the tide against antibiotics by outsmarting our wonder drugs. This video explores the surprising reasons. BY THE NEW YORK TIMES
For the generations of high school students whose English class assignments included reading Joseph Kesselring’s play, “Arsenic and Old Lace,” the idea of arsenic as an aid to health seems either amusing or frightening.
But a group of Florida International University researchers from the Herbert Wertheim College of Medicine and an international team from Japan have discovered a new broad-spectrum antibiotic that contains arsenic, FIU announced Tuesday.
Broad-spectrum means “an antibiotic is effective against many types of bacteria,” FIU’s Barry Rosen, the co-senior author of the study that was published Monday in Nature’s Communication Biology, said of arsinothricin, also known as AST.
This is important, FIU’s scientists explained, because antibiotic resistance — when the body’s immune system doesn’t react to the antibiotic’s healing properties and the germs, or bacteria, are not killed or stopped as expected — is a growing problem. The FIU medical school called antibiotic resistance “one of the biggest public health threats of our time.”
Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine. Doug Garland FIU
ANTIBIOTIC RESISTANCE CRISIS
According to the Centers for Disease Control and Prevention, at least two million people get infected with bacteria that prove resistant to antibiotics and at least 23,000 people die every year as a direct result of these infections.
In February 2018, the World Health Organization warned that “new resistance mechanisms are emerging and spreading globally, threatening our ability to treat common infectious diseases.”
WHO lists infections like pneumonia, tuberculosis, blood poisoning, gonorrhea, and food-borne diseases as those that “are becoming harder, and sometimes impossible, to treat as antibiotics become less effective.”
NATURAL PRODUCT
Rosen said the arsinothricin antibiotic is “a natural product made by soil bacteria and is effective against many types of bacteria, which is what broad-spectrum means. Arsinothricin is the first and only known natural arsenic-containing antibiotic, and we have great hopes for it.”
Although AST contains arsenic, the researchers tested AST toxicity on human blood cells and found that it didn’t kill human cells in the tissue culture.
An E. coli outbreak forced 43 Chipotle locations to temporarily close their doors this week — here are the basics on how outbreaks happen and what symptoms to look for. By McClatchy
According to FIU, the new antibiotic was found to be “very effective” against E. coli, which can cause severe intestinal infections, and carbapenem-resistant Enterobacter cloacae, which has been linked to increasing infections in neonatal and intensive care units.
The U.S. and Japan team of scientists also found that AST worked against Mycobacterium bovis, which causes tuberculosis in cattle. “This suggests the potential for treating human tuberculosis,” FIU said in its media release.
FURTHER STUDY
The next step — and it’s lengthy — is further testing to determine the antibiotic’s effectiveness and toxicity in animals and humans, patenting the discovery and working with the pharmaceutical industry to turn this into a drug that can be prescribed for the public. This, FIU says, is a costly process that could take 10 years.
“We are running out of tools to fight these diseases. We need a new potent antibiotic to solve this problem,” said Masafumi Yoshinaga, the other co-senior author who is with the Department of Cellular Biology and Pharmacology at FIU. “We showed that this new novel arsenic compound can be a potent antibiotic.”
Researchers from Japan’s Institute for Agro-Environmental Sciences, NARO, were also part of the study’s team with FIU.
As for grade school memories of “Arsenic and Old Lace,” or fans of Frank Capra’s 1944 film adaptation, it’s time to rethink.
“People get scared when they hear the word arsenic because it can be a toxin and carcinogen, but the use of arsenicals as antimicrobials and anti-cancer agents is well established,” Rosen said in the news release. He cited examples including scientist Paul Ehrlich, who won the 1908 Nobel Prize in medicine when he found an arsenic-based cure for syphilis. Arsenicals, FIU noted, “are still used to treat tropical diseases, preventing infectious diseases in poultry, and as a chemotherapeutic treatment for leukemia.”
Rosen added that while the majority of potential drugs fail in the clinical trial stage, the work is still worth the effort. “If you don’t bring new drugs into the pipeline, you won’t find the ones that work.”
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A study published in the Journal of the Pediatric Infectious Diseases Society in 2018 found that just under 70,000 children are sent to the emergency room each year for an adverse reaction to antibiotics. Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine. A study published in the Journal of the Pediatric Infectious Diseases Society in 2018 found that just under 70,000 children are sent to the emergency room each year for an adverse reaction to antibiotics. Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine.
1
of 2
Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine. FIU WERTHEIM COLLEGE OF MEDICINE
GALLERY
Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine.A study published in the Journal of the Pediatric Infectious Diseases Society in 2018 found that just under 70,000 children are sent to the emergency room each year for an adverse reaction to antibiotics.
HOWARD COHEN
305-376-3619
Miami Herald Real Time/Breaking News reporter Howard Cohen, a 2017 Media Excellence Awards winner, has covered pop music, theater, health and fitness, obituaries, municipal government and general assignment. He started his career in the Features department at the Miami Herald in 1991.
Read more here: www.miamiherald.com/living/health-fitness/article229314199.html#storylink=cpy
Miami Herald Logo
Are your antibiotics not working anymore? Arsenic could be a lifesaver, research says | Miami Herald
HEALTH & FITNESS
Are your antibiotics not working anymore? Arsenic could be a lifesaver, research says
BY HOWARD COHEN
APRIL 16, 2019 12:03 PM, UPDATED APRIL 16, 2019 02:52 PM
Bacteria are rebelling. They’re turning the tide against antibiotics by outsmarting our wonder drugs. This video explores the surprising reasons. BY THE NEW YORK TIMES
For the generations of high school students whose English class assignments included reading Joseph Kesselring’s play, “Arsenic and Old Lace,” the idea of arsenic as an aid to health seems either amusing or frightening.
But a group of Florida International University researchers from the Herbert Wertheim College of Medicine and an international team from Japan have discovered a new broad-spectrum antibiotic that contains arsenic, FIU announced Tuesday.
Broad-spectrum means “an antibiotic is effective against many types of bacteria,” FIU’s Barry Rosen, the co-senior author of the study that was published Monday in Nature’s Communication Biology, said of arsinothricin, also known as AST.
This is important, FIU’s scientists explained, because antibiotic resistance — when the body’s immune system doesn’t react to the antibiotic’s healing properties and the germs, or bacteria, are not killed or stopped as expected — is a growing problem. The FIU medical school called antibiotic resistance “one of the biggest public health threats of our time.”
Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine. Doug Garland FIU
ANTIBIOTIC RESISTANCE CRISIS
According to the Centers for Disease Control and Prevention, at least two million people get infected with bacteria that prove resistant to antibiotics and at least 23,000 people die every year as a direct result of these infections.
In February 2018, the World Health Organization warned that “new resistance mechanisms are emerging and spreading globally, threatening our ability to treat common infectious diseases.”
WHO lists infections like pneumonia, tuberculosis, blood poisoning, gonorrhea, and food-borne diseases as those that “are becoming harder, and sometimes impossible, to treat as antibiotics become less effective.”
NATURAL PRODUCT
Rosen said the arsinothricin antibiotic is “a natural product made by soil bacteria and is effective against many types of bacteria, which is what broad-spectrum means. Arsinothricin is the first and only known natural arsenic-containing antibiotic, and we have great hopes for it.”
Although AST contains arsenic, the researchers tested AST toxicity on human blood cells and found that it didn’t kill human cells in the tissue culture.
An E. coli outbreak forced 43 Chipotle locations to temporarily close their doors this week — here are the basics on how outbreaks happen and what symptoms to look for. By McClatchy
According to FIU, the new antibiotic was found to be “very effective” against E. coli, which can cause severe intestinal infections, and carbapenem-resistant Enterobacter cloacae, which has been linked to increasing infections in neonatal and intensive care units.
The U.S. and Japan team of scientists also found that AST worked against Mycobacterium bovis, which causes tuberculosis in cattle. “This suggests the potential for treating human tuberculosis,” FIU said in its media release.
FURTHER STUDY
The next step — and it’s lengthy — is further testing to determine the antibiotic’s effectiveness and toxicity in animals and humans, patenting the discovery and working with the pharmaceutical industry to turn this into a drug that can be prescribed for the public. This, FIU says, is a costly process that could take 10 years.
“We are running out of tools to fight these diseases. We need a new potent antibiotic to solve this problem,” said Masafumi Yoshinaga, the other co-senior author who is with the Department of Cellular Biology and Pharmacology at FIU. “We showed that this new novel arsenic compound can be a potent antibiotic.”
Researchers from Japan’s Institute for Agro-Environmental Sciences, NARO, were also part of the study’s team with FIU.
As for grade school memories of “Arsenic and Old Lace,” or fans of Frank Capra’s 1944 film adaptation, it’s time to rethink.
“People get scared when they hear the word arsenic because it can be a toxin and carcinogen, but the use of arsenicals as antimicrobials and anti-cancer agents is well established,” Rosen said in the news release. He cited examples including scientist Paul Ehrlich, who won the 1908 Nobel Prize in medicine when he found an arsenic-based cure for syphilis. Arsenicals, FIU noted, “are still used to treat tropical diseases, preventing infectious diseases in poultry, and as a chemotherapeutic treatment for leukemia.”
Rosen added that while the majority of potential drugs fail in the clinical trial stage, the work is still worth the effort. “If you don’t bring new drugs into the pipeline, you won’t find the ones that work.”
RELATED STORIES FROM MIAMI HERALD
FOOD-DRINK
Salmonella outbreak gets melon at Walmart, Target, Whole Foods and other chains recalled
APRIL 13, 2019 09:22 AM
HEALTH-CARE
Patients got more MRSA infections at Jackson Health than at any other U.S. hospital
JUNE 04, 2018 05:40 PM
STATE
These Kentucky hospitals had more MRSA infections than almost all others in the U.S.
JUNE 01, 2018 01:38 PM
A study published in the Journal of the Pediatric Infectious Diseases Society in 2018 found that just under 70,000 children are sent to the emergency room each year for an adverse reaction to antibiotics. Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine. A study published in the Journal of the Pediatric Infectious Diseases Society in 2018 found that just under 70,000 children are sent to the emergency room each year for an adverse reaction to antibiotics. Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine.
1
of 2
Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine. FIU WERTHEIM COLLEGE OF MEDICINE
GALLERY
Florida International University’s team of researchers from the Herbert Wertheim College of Medicine, along with a team of scientists in Japan, discovered a new arsenic-based broad-spectrum antibiotic called arsinothricin or AST. FIU researchers are (left-right) Adriana Emilce Galvan, Masafumi Yoshinaga, Kunie Sakurai, Venkadesh Sarkarai Nadar, Jian Chen and Barry Rosen. They were photographed in Rosen’s lab at Herbert Wertheim College of Medicine.A study published in the Journal of the Pediatric Infectious Diseases Society in 2018 found that just under 70,000 children are sent to the emergency room each year for an adverse reaction to antibiotics.
HOWARD COHEN
305-376-3619
Miami Herald Real Time/Breaking News reporter Howard Cohen, a 2017 Media Excellence Awards winner, has covered pop music, theater, health and fitness, obituaries, municipal government and general assignment. He started his career in the Features department at the Miami Herald in 1991.
Read more here: www.miamiherald.com/living/health-fitness/article229314199.html#storylink=cpy