Post by onefreetrajectory on Oct 7, 2015 20:17:51 GMT
I find the references to 4k score being a genetic test confusing as a non MD.When I hear Genetic test, I think of one's DNA and genetic predisposition, or malformation related to a specific disease. Women getting genetic tests for breast cancer are confirming a genetic predisposiiton related normally to family history.
Then I have heard of genes specific to cancers. Again, I think of DNA, presumably an individual's DNA, but damaged in a way that enables the cancer. Cancer cells DNA is analyzed and individual targeting treatments can be used to target and kill the cancer, or make the immune system smart to identify those cancer cells as foes and kill them.
Then for 4K Score, I looked up Kallikreins:
Tissue kallikreins
Distinct from plasma kallikrein, tissue kallikreins (KLKs) are expressed throughout the human body and perform various physiological roles. As some kallikreins are able to catalyse the activation of other kallikreins, several cascades involving these proteases have been implicated in the regulation of homeostatic functions.
Function
Similar to KLKB1, three tissue kallikreins KLK1, KLK2 and KLK12 also participate in regulation of blood pressure via the activation of bradykinin.[5] KLK2, KLK3, KLK4, KLK5 and KLK14 are expressed in the prostate and are thought to be responsible for regulating semen liquefaction through hydrolysis of seminogelin.[6][7] Desquamation of the skin is likely controlled by KLK5, KLK7 and KLK14, which are expressed in the outermost layer of the epidermis and cleave cellular adhesion proteins.[8] Additionally, KLK6 and KLK8 are associated with neuronal plasticity in the central nervous system.[9]
Genes
There are 15 known human tissue kallikreins: KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15
Clinical significance
Kallikrein-related peptidases are targets of active investigation by drug researchers as possible biomarkers for cancer
Prostate-specific antigen (PSA; hk3, human kallikrein gene 3) and human glandular kallikrein (hK2) are used as tumor markers for prostate cancer.
For a layman, can anyone provide the high level relationship between one's DNA, the human chromosome, and kallikrein enzymes?
Then I have heard of genes specific to cancers. Again, I think of DNA, presumably an individual's DNA, but damaged in a way that enables the cancer. Cancer cells DNA is analyzed and individual targeting treatments can be used to target and kill the cancer, or make the immune system smart to identify those cancer cells as foes and kill them.
Then for 4K Score, I looked up Kallikreins:
Tissue kallikreins
Distinct from plasma kallikrein, tissue kallikreins (KLKs) are expressed throughout the human body and perform various physiological roles. As some kallikreins are able to catalyse the activation of other kallikreins, several cascades involving these proteases have been implicated in the regulation of homeostatic functions.
Function
Similar to KLKB1, three tissue kallikreins KLK1, KLK2 and KLK12 also participate in regulation of blood pressure via the activation of bradykinin.[5] KLK2, KLK3, KLK4, KLK5 and KLK14 are expressed in the prostate and are thought to be responsible for regulating semen liquefaction through hydrolysis of seminogelin.[6][7] Desquamation of the skin is likely controlled by KLK5, KLK7 and KLK14, which are expressed in the outermost layer of the epidermis and cleave cellular adhesion proteins.[8] Additionally, KLK6 and KLK8 are associated with neuronal plasticity in the central nervous system.[9]
Genes
There are 15 known human tissue kallikreins: KLK1, KLK2, KLK3, KLK4, KLK5, KLK6, KLK7, KLK8, KLK9, KLK10, KLK11, KLK12, KLK13, KLK14, KLK15
Clinical significance
Kallikrein-related peptidases are targets of active investigation by drug researchers as possible biomarkers for cancer
Prostate-specific antigen (PSA; hk3, human kallikrein gene 3) and human glandular kallikrein (hK2) are used as tumor markers for prostate cancer.
For a layman, can anyone provide the high level relationship between one's DNA, the human chromosome, and kallikrein enzymes?
