Post by icemandios on Nov 9, 2020 14:17:17 GMT
Phio Announces Positive In Vivo Data On Combination PD-1 And TIGIT Checkpoint Blockade With INTASYL In A Single Therapeutic For Cancer Treatment
The new data was presented at the SITC 2020 Virtual Scientific Program
MARLBOROUGH, Mass. , Nov. 9, 2020 /PRNewswire/ -- Phio Pharmaceuticals Corp. (Nasdaq: PHIO), a biotechnology company developing the next generation of immuno-oncology therapeutics based on its proprietary self-delivering RNAi (INTASYL™) therapeutic platform, today announced positive data from an in vivo study that shows the strong antitumoral efficacy of individual INTASYL pipeline products, including PH-762, PH-790 and PH-804, can be further improved by combining them in a single therapeutic. These data were presented during The Society for Immunotherapy of Cancer (SITC) 35 th Anniversary Annual Meeting - Abstract 198: "Combination intratumoral treatment with INTASYL™ self-delivering RNAi targeting TIGIT and PD-1/PD-L1 improves tumor control compared to monotherapy in a CT26 model of murine colorectal cancer ".
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These results build on previously published data showing that intratumoral delivery of individual INTASYL compounds inhibited tumor growth. The data presented at SITC 2020 demonstrated that such antitumoral effect can be significantly improved by combining different INTASYL compounds. Therefore, the Company believes the use of our pipeline products in combination show great promise in the treatment of solid tumors.
The Company's pipeline programs PH-762, PH-790 and PH-804 are INTASYL compounds designed to silence the expression of PD-1, PD-L1 and TIGIT, respectively, which are proteins linked to reduced immune cell function in cancer patients. Previously, a series of preclinical in vivo studies in tumor models were conducted and the resulting data showed dose-dependent attenuated tumor growth for the INTASYL compounds compared to control groups. The new data shows that whereas in vivo efficacy of INTASYL monotherapy was analogous to that of systemically delivered antibody therapy for each target, combining INTASYL targeting TIGIT + PD-1 or TIGIT + PD-L1 inhibited tumor growth even further, without having a negative impact on the tolerability of the treatment.
"Recent study results with systemic immune checkpoint blockade antibody therapies shows promise of combination therapy, but the serious immune-related adverse events seen with such antibody therapy results in significant hurdles for realizing their maximum clinical potential when these antibodies are used in combination. INTASYL therapies administered intratumorally represent an attractive alternative strategy," said Dr. Simon Fricker , Phio's VP of Research. "Whereas our prior monotherapy data already looked very promising, the new combination results are even more exciting, especially considering that multiple INTASYL compounds can be easily and cost effectively combined in a single therapeutic."
A poster further detailing the data presented at the SITC 2020 Virtual Scientific Program will be made available under the "Investors – Events and Presentations" section of the Company's website ( click here ).
About Phio Pharmaceuticals Corp.
Phio Pharmaceuticals Corp. (Nasdaq: PHIO) is a biotechnology company developing the next generation of immuno-oncology therapeutics based on its self-delivering RNAi (INTASYL™) therapeutic platform. The Company's efforts are focused on silencing tumor-induced suppression of the immune system through its proprietary INTASYL platform with utility in immune cells and/or the tumor micro-environment. Our goal is to develop powerful INTASYL therapeutic compounds that can weaponize immune effector cells to overcome tumor immune escape, thereby providing patients a powerful new treatment option that goes beyond current treatment modalities. For additional information, visit the Company's website, www.phiopharma.com .