Post by deborah on Apr 15, 2019 17:53:25 GMT
This study was released in the April 2019 Clinical Nutrition Journal April 2019 Volume 24, Pages 77–82
www.clinicalnutritionexperimental.com/article/S2352-9393(18)30084-8/fulltext
All people on high blood pressure medication should pay attention to this statement.
In this study we observed a pulse pressure lowering effect of daily 15 μg calcifediol supplementation. The differences between treatment arms were consistent over time points, and of such a magnitude that significance was reached, despite the low sample size.
Summary
Vitamin D is proposed as an antihypertensive agent, but current evidence is inconclusive. Calcifediol is more potent in raising vitamin D status. It might, therefore, be more effective in lowering pulse pressure than cholecalciferol especially in patients with low vitamin D status and high levels of parathyroid hormone (PTH). This study investigated the efficacy of calcifediol on pulse pressure in older adults with vitamin D deficiency and elevated PTH levels. Supplementation with 15 μg calcifediol resulted in lower pulse pressure (Δ 35.4 mm Hg, 95%CI: 4.8, 66.1 mm Hg, P = 0.021) and PTH levels (Δ 1.83 pmol/l, 95%CI: −0.1, 3.7 pmol/l, P = 0.065) compared to 5 μg calcifediol. These effects were observed in a limited sample size of 16 older adults and therefore need confirmation in a larger trial.
In conclusion, supplementation with 15 μg calcifediol might be an effective way to reduce pulse pressure in elderly with vitamin D deficiency and elevated PTH levels.
www.clinicalnutritionexperimental.com/article/S2352-9393(18)30084-8/fulltext
All people on high blood pressure medication should pay attention to this statement.
In this study we observed a pulse pressure lowering effect of daily 15 μg calcifediol supplementation. The differences between treatment arms were consistent over time points, and of such a magnitude that significance was reached, despite the low sample size.
Summary
Vitamin D is proposed as an antihypertensive agent, but current evidence is inconclusive. Calcifediol is more potent in raising vitamin D status. It might, therefore, be more effective in lowering pulse pressure than cholecalciferol especially in patients with low vitamin D status and high levels of parathyroid hormone (PTH). This study investigated the efficacy of calcifediol on pulse pressure in older adults with vitamin D deficiency and elevated PTH levels. Supplementation with 15 μg calcifediol resulted in lower pulse pressure (Δ 35.4 mm Hg, 95%CI: 4.8, 66.1 mm Hg, P = 0.021) and PTH levels (Δ 1.83 pmol/l, 95%CI: −0.1, 3.7 pmol/l, P = 0.065) compared to 5 μg calcifediol. These effects were observed in a limited sample size of 16 older adults and therefore need confirmation in a larger trial.
In conclusion, supplementation with 15 μg calcifediol might be an effective way to reduce pulse pressure in elderly with vitamin D deficiency and elevated PTH levels.